Blar i NTNU Open på forfatter "Gultekin, Okan"
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Cd11c‐cd8 spatial cross presentation: A novel approach to link immune surveillance and patient survival in soft tissue sarcoma
Su, Yanhong; Tsagozis, Panagiotis; Papakonstantinou, Andri; Tobin, Nicholas P.; Gultekin, Okan; Malmerfelt, Anna; Ingelshed, Katrine; Neo, Shi Yong; Lundquist, Johanna; Chaabane, Wiem; Nisancioglu, Maya H.; Leiss, Lina; Östman, Arne; Bergh, Jonas; Sedimbi, Saikiran K.; Lehti, Kaisa; Lehti, Kaisa; Lundqvist, Andreas; Stragliotto, Christina L.; Haglund, Felix; Ehnman, Monika (Peer reviewed; Journal article, 2021)Checkpoint inhibitors are slowly being introduced in the care of specific sarcoma subtypes such as undifferentiated pleomorphic sarcoma, alveolar soft part sarcoma, and angiosarcoma even though formal indication is lacking. ... -
Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance
Pietilä, Elina A.; Gonzalez-Molina, Jordi.; Moyano-Galceran, Lidia; Jamalzadeh, Sanaz; Zhang, Kaiyang; Lehtinen, Laura; Turunen, S Pauliina; Martins, Tomás A; Gultekin, Okan; Lamminen, Tarja; Kaipio, Katja; Joneborg, Ulrika; Hynninen, Johanna; Hietanen, Sakara; Grénman, Seija; Lehtonen, Rainer; Hautaniemi, Sampsa; Carpén, Olli; Carlson, Joseph W.; Lehti, Kaisa (Peer reviewed; Journal article, 2021)Due to its dynamic nature, the evolution of cancer cell-extracellular matrix (ECM) crosstalk, critically affecting metastasis and treatment resistance, remains elusive. Our results show that platinum-chemotherapy itself ... -
FOXP3+ T cells in uterine sarcomas are associated with favorable prognosis, low extracellular matrix expression and reduced YAP activation
Gultekin, Okan; Gonzalez-Molina, Jordi; Hardell, Elin; Moyano-Galceran, Lidia; Mitsios, Nicholas; Mulder, Jan; Kokaraki, Georgia; Isaksson, Anders; Sarhan, Dhifaf; Lehti, Kaisa; Carlson, Joseph W. (Peer reviewed; Journal article, 2021)Uterine sarcomas are rare but deadly malignancies without effective treatment. Immunotherapy is a promising new approach to treat these tumors but has shown heterogeneous effects in sarcoma patients. With the goal of ... -
MMP14 expression and collagen remodelling support uterine leiomyosarcoma aggressiveness
Gonzalez-Molina, Jordi; Hahn, Paula; Falcão, Raul Maia; Gultekin, Okan; Kokaraki, Georgia; Zanfagnin, Valentina; Braz Petta, Tirzah; Lehti, Kaisa Irene; Carlson, Joseph W. (Peer reviewed; Journal article, 2023)Fibrillar collagen deposition, stiffness and downstream signalling support the development of leiomyomas (LMs), common benign mesenchymal tumours of the uterus, and are associated with aggressiveness in multiple carcinomas. ...